What safety precautions should you take when working with acetic anhydride.
Synthesis of esters using acetic anhydride1 safety precautions - treat concentrated h2so4 with respect--clean up any and all spills, however small rinse exposed areas of your skin immediately with lots of water experiment 7 synthesis of esters using acetic anhydride. Acetic anhydride is an esterification agent for use in prepn of modified food starch and for acetylation of monoglycerides acetic anhydride is a versatile reagent for acetylations, the introduction of acetyl groups to organic substrates.
Safety precautions for synthesis of acetic anhydride acetic anhydride acetic anhydride is an irritant and also flammable, therefore gloves and goggles should be worn at all times during the experiment it is reactive to water, so in the case of fire, alcohol foam or carbon dioxide is preferred to use as an extinguisher. Synthesis of aspirin learning goals 1 to synthesize aspirin from salicylic acid and acetic anhydride 2 to purify the crude product by recrystallization introduction most drugs are chemical compounds which are described as organic compounds because they are comprised primarily of the elements carbon, hydrogen and oxygen.
Acetic anhydride is an irritant and also flammable, therefore gloves and goggles should be worn at all times during the experiment it is reactive to water, so in the case of fire, alcohol foam or carbon dioxide is preferred to use as an extinguisher. Prepared in the context of cooperation between the international programme on chemical safety & the commission of the european communities (c) ipcs cec 1994 no modifications to the international version have been made except to add the osha pels, niosh rels and niosh idlh values.
A balanced equation for the synthesis of aspirin from salicylic acid and acetic anhydride is the following: salicylic acid + acetic anhydride – acetylsalicylic acid + acetic acid (c7h6o3) + (c4h6o3) – (c9h8o4) + (c2h4o2) 0 3623 mol + 0 3623 mol 0 3623 mol + 0 3623 mol as we can see above the mole ratio is 1:1:1:1:1. Safety hazards of acetic anhydride to potentially exposed workers acetic anhydride page 2 of 6 acetic anhydride forms acetic acid when mixed with water acetic anhydride must be stored to avoid contact with boiling water steam boric acid oxidizing. The experiment starts by combining such chemicals such as salicylic acid and acetic anhydride the synthesis of aspirin is classified as an esterification reaction this is a substitution reaction where the alcohol group from salicylic acid reacts with ascetic anhydride to form an ester, (acetylsalicylic acid) which is commonly known as aspirin.
The synthesis of aspirin is classified as an esterification reaction salicylic acid is treated with acetic anhydride, an acid derivative, causing a chemical reaction that turns salicylic acid's hydroxyl group into an ester group (r-oh †’ r-ococh3) this process yields aspirin and acetic acid, which is considered a by-product of this reaction. Acetic anhydride is an irritant and also flammable, therefore gloves and goggles should be worn at all times during the experiment it is reactive to water, so in the case of fire, alcohol foam or carbon dioxide is preferred to use as an extinguisher this chemical has harmful fumes and use of a fume hood is strongly recommended. Accordingly acetic anhydride was prepared by placing 20 grams of dry acetic acid in a flask, fitted to a condenser and then dropping 20 grams of oxalyl chloride in the acetic acid the water was removed from the acid by freezing it in a freezing mixture until there was just a little liquid left in the center. Aspirin is prepared by the esterification of salicylic acid with acetic anhydride under acidic conditions the phenol group in salicylic acid is replaced by a carboxyl group through electrophilic substitution the mechanism for the reaction can be summarized as follows: essay on synthesis of aspirin synthesis of aspirin.
Forms acetic acid when mixed with water major fires must be extinguished with large amounts of water from a distance transport emergency card: tec (r)-80s1715 nfpa code: h 2 f 2 r 1 w card has been partially updated in july 2007: see occupational exposure limits.